The GAME USB port is designed specifically for game and chat audio, not for device control or configuration.
It allows you to send audio into the interface separately from your main streaming setup.
Although the GAME USB port is recognized as a standard USB connection, it doesn’t allow the M-Game Control Panel software to control the interface. It will only send and receive audio.
To control the M-Game hardware, you must connect the STREAM USB port to your streaming computer running the M-Game Control Panel software.